Pesquisa | BVS IEC

1.

Profound phenotypic and epigenetic heterogeneity of the HIV-1-infected CD4⁺ T cell reservoir.

Wu, Vincent H; Nordin, Jayme M L; Nguyen, Son; Joy, Jaimy; Mampe, Felicity; Del Rio Estrada, Perla M; Torres-Ruiz, Fernanda; González-Navarro, Mauricio; Luna-Villalobos, Yara Andrea; Ávila-Ríos, Santiago; Reyes-Terán, Gustavo; Tebas, Pablo; Montaner, Luis J; Bar, Katharine J; Vella, Laura A; Betts, Michael R.

Nat Immunol ; 24(2): 359-370, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36536105

2.

Phenotypic signatures of immune selection in HIV-1 reservoir cells.

Sun, Weiwei; Gao, Ce; Hartana, Ciputra Adijaya; Osborn, Matthew R; Einkauf, Kevin B; Lian, Xiaodong; Bone, Benjamin; Bonheur, Nathalie; Chun, Tae-Wook; Rosenberg, Eric S; Walker, Bruce D; Yu, Xu G; Lichterfeld, Mathias.

Nature ; 614(7947): 309-317, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36599977

3.

HIV silencing and cell survival signatures in infected T cell reservoirs.

Clark, Iain C; Mudvari, Prakriti; Thaploo, Shravan; Smith, Samuel; Abu-Laban, Mohammad; Hamouda, Mehdi; Theberge, Marc; Shah, Sakshi; Ko, Sung Hee; Pérez, Liliana; Bunis, Daniel G; Lee, James S; Kilam, Divya; Zakaria, Saami; Choi, Sally; Darko, Samuel; Henry, Amy R; Wheeler, Michael A; Hoh, Rebecca; Butrus, Salwan; Deeks, Steven G; Quintana, Francisco J; Douek, Daniel C; Abate, Adam R; Boritz, Eli A.

Nature ; 614(7947): 318-325, 2023 02.

Artigo em Inglês | MEDLINE | ID: mdl-36599978

4.

Long-acting capsid inhibitor protects macaques from repeat SHIV challenges.

Vidal, Samuel J; Bekerman, Elena; Hansen, Derek; Lu, Bing; Wang, Kelly; Mwangi, Judy; Rowe, William; Campigotto, Federico; Zheng, Jim; Kato, Darryl; Chandrashekar, Abishek; Barrett, Julia; Patel, Shivani; Wan, Huahua; Anioke, Tochi; Mercado, Noe B; Nkolola, Joseph P; Ferguson, Melissa J; Rinaldi, William J; Callebaut, Christian; Blair, Wade; Cihlar, Tomas; Geleziunas, Romas; Yant, Stephen R; Barouch, Dan H.

Nature ; 601(7894): 612-616, 2022 01.

Artigo em Inglês | MEDLINE | ID: mdl-34875675

5.

Prolonged viral suppression with anti-HIV-1 antibody therapy.

Gaebler, Christian; Nogueira, Lilian; Stoffel, Elina; Oliveira, Thiago Y; Breton, Gaëlle; Millard, Katrina G; Turroja, Martina; Butler, Allison; Ramos, Victor; Seaman, Michael S; Reeves, Jacqueline D; Petroupoulos, Christos J; Shimeliovich, Irina; Gazumyan, Anna; Jiang, Caroline S; Jilg, Nikolaus; Scheid, Johannes F; Gandhi, Rajesh; Walker, Bruce D; Sneller, Michael C; Fauci, Anthony; Chun, Tae-Wook; Caskey, Marina; Nussenzweig, Michel C.

Nature ; 606(7913): 368-374, 2022 06.

Artigo em Inglês | MEDLINE | ID: mdl-35418681

6.

HIV reservoirs as obstacles and opportunities for an HIV cure.

Chun, Tae-Wook; Moir, Susan; Fauci, Anthony S.

Nat Immunol ; 16(6): 584-9, 2015 Jun.

Artigo em Inglês | MEDLINE | ID: mdl-25990814

7.

Targeting the Latent Reservoir for HIV-1.

Sengupta, Srona; Siliciano, Robert F.

Immunity ; 48(5): 872-895, 2018 05 15.

Artigo em Inglês | MEDLINE | ID: mdl-29768175

8.

Adjunctive Dexamethasone for Tuberculous Meningitis in HIV-Positive Adults.

Donovan, Joseph; Bang, Nguyen D; Imran, Darma; Nghia, Ho D T; Burhan, Erlina; Huong, Dau T T; Hiep, Nguyen T T; Ngoc, Lam H B; Thanh, Dang V; Thanh, Nguyen T; Wardhani, Anna L S; Maharani, Kartika; Gasmara, Cakra P; Hanh, Nguyen H H; Oanh, Pham K N; Estiasari, Riwanti; Thu, Do D A; Kusumaningrum, Ardiana; Dung, Le T; Giang, Do C; Ha, Dang T M; Lan, Nguyen H; Chau, Nguyen V V; Nguyet, Nguyen T M; Geskus, Ronald B; Thuong, Nguyen T T; Kestelyn, Evelyne; Hamers, Raph L; Phu, Nguyen H; Thwaites, Guy E.

N Engl J Med ; 389(15): 1357-1367, 2023 Oct 12.

Artigo em Inglês | MEDLINE | ID: mdl-37819954

9.

Early antiretroviral therapy in SIV-infected rhesus macaques reveals a multiphasic, saturable dynamic accumulation of the rebound competent viral reservoir.

Keele, Brandon F; Okoye, Afam A; Fennessey, Christine M; Varco-Merth, Benjamin; Immonen, Taina T; Kose, Emek; Conchas, Andrew; Pinkevych, Mykola; Lipkey, Leslie; Newman, Laura; Macairan, Agatha; Bosche, Marjorie; Bosche, William J; Berkemeier, Brian; Fast, Randy; Hull, Mike; Oswald, Kelli; Shoemaker, Rebecca; Silipino, Lorna; Gorelick, Robert J; Duell, Derick; Marenco, Alejandra; Brantley, William; Smedley, Jeremy; Axthelm, Michael; Davenport, Miles P; Lifson, Jeffrey D; Picker, Louis J.

PLoS Pathog ; 20(4): e1012135, 2024 Apr.

Artigo em Inglês | MEDLINE | ID: mdl-38593120

10.

The timing of HIV-1 infection of cells that persist on therapy is not strongly influenced by replication competency or cellular tropism of the provirus.

Joseph, Sarah B; Abrahams, Melissa-Rose; Moeser, Matthew; Tyers, Lynn; Archin, Nancie M; Council, Olivia D; Sondgeroth, Amy; Spielvogel, Ean; Emery, Ann; Zhou, Shuntai; Doolabh, Deelan; Ismail, Sherazaan D; Karim, Salim Abdool; Margolis, David M; Pond, Sergei Kosakovsky; Garrett, Nigel; Swanstrom, Ronald; Williamson, Carolyn.

PLoS Pathog ; 20(2): e1011974, 2024 Feb.

Artigo em Inglês | MEDLINE | ID: mdl-38422171

11.

CD4⁺ T cell signatures in HIV infection.

Gubser, Celine; Pitman, Matthew C; Lewin, Sharon R.

Nat Immunol ; 20(8): 948-950, 2019 08.

Artigo em Inglês | MEDLINE | ID: mdl-31308542

12.

CTLA-4⁺PD-1^- Memory CD4⁺ T Cells Critically Contribute to Viral Persistence in Antiretroviral Therapy-Suppressed, SIV-Infected Rhesus Macaques.

McGary, Colleen S; Deleage, Claire; Harper, Justin; Micci, Luca; Ribeiro, Susan P; Paganini, Sara; Kuri-Cervantes, Leticia; Benne, Clarisse; Ryan, Emily S; Balderas, Robert; Jean, Sherrie; Easley, Kirk; Marconi, Vincent; Silvestri, Guido; Estes, Jacob D; Sekaly, Rafick-Pierre; Paiardini, Mirko.

Immunity ; 47(4): 776-788.e5, 2017 10 17.

Artigo em Inglês | MEDLINE | ID: mdl-29045906

13.

Systemic HIV and SIV latency reversal via non-canonical NF-κB signalling in vivo.

Nixon, Christopher C; Mavigner, Maud; Sampey, Gavin C; Brooks, Alyssa D; Spagnuolo, Rae Ann; Irlbeck, David M; Mattingly, Cameron; Ho, Phong T; Schoof, Nils; Cammon, Corinne G; Tharp, Greg K; Kanke, Matthew; Wang, Zhang; Cleary, Rachel A; Upadhyay, Amit A; De, Chandrav; Wills, Saintedym R; Falcinelli, Shane D; Galardi, Cristin; Walum, Hasse; Schramm, Nathaniel J; Deutsch, Jennifer; Lifson, Jeffrey D; Fennessey, Christine M; Keele, Brandon F; Jean, Sherrie; Maguire, Sean; Liao, Baolin; Browne, Edward P; Ferris, Robert G; Brehm, Jessica H; Favre, David; Vanderford, Thomas H; Bosinger, Steven E; Jones, Corbin D; Routy, Jean-Pierre; Archin, Nancie M; Margolis, David M; Wahl, Angela; Dunham, Richard M; Silvestri, Guido; Chahroudi, Ann; Garcia, J Victor.

Nature ; 578(7793): 160-165, 2020 02.

Artigo em Inglês | MEDLINE | ID: mdl-31969707

14.

CRISPR editing of CCR5 and HIV-1 facilitates viral elimination in antiretroviral drug-suppressed virus-infected humanized mice.

Dash, Prasanta K; Chen, Chen; Kaminski, Rafal; Su, Hang; Mancuso, Pietro; Sillman, Brady; Zhang, Chen; Liao, Shuren; Sravanam, Sruthi; Liu, Hong; Waight, Emiko; Guo, Lili; Mathews, Saumi; Sariyer, Rahsan; Mosley, R Lee; Poluektova, Larisa Y; Caocci, Maurizio; Amini, Shohreh; Gorantla, Santhi; Burdo, Tricia H; Edagwa, Benson; Gendelman, Howard E; Khalili, Kamel.

Proc Natl Acad Sci U S A ; 120(19): e2217887120, 2023 05 09.

Artigo em Inglês | MEDLINE | ID: mdl-37126704

15.

Biphasic decay of intact SHIV genomes following initiation of antiretroviral therapy complicates analysis of interventions targeting the reservoir.

Kumar, Mithra R; Fray, Emily J; Bender, Alexandra M; Zitzmann, Carolin; Ribeiro, Ruy M; Perelson, Alan S; Barouch, Dan H; Siliciano, Janet D; Siliciano, Robert F.

Proc Natl Acad Sci U S A ; 120(43): e2313209120, 2023 Oct 24.

Artigo em Inglês | MEDLINE | ID: mdl-37844236

16.

Structure-based design of a SARS-CoV-2 Omicron-specific inhibitor.

Yang, Kailu; Wang, Chuchu; Kreutzberger, Alex J B; White, K Ian; Pfuetzner, Richard A; Esquivies, Luis; Kirchhausen, Tomas; Brunger, Axel T.

Proc Natl Acad Sci U S A ; 120(13): e2300360120, 2023 03 28.

Artigo em Inglês | MEDLINE | ID: mdl-36940324

17.

Preferential selection of viral escape mutants by CD8+ T cell 'sieving' of SIV reactivation from latency.

Docken, Steffen S; McCormick, Kevin; Pampena, M Betina; Samer, Sadia; Lindemuth, Emily; Pinkevych, Mykola; Viox, Elise G; Wu, Yuhuang; Schlub, Timothy E; Cromer, Deborah; Keele, Brandon F; Paiardini, Mirko; Betts, Michael R; Bar, Katharine J; Davenport, Miles P.

PLoS Pathog ; 19(11): e1011755, 2023 Nov.

Artigo em Inglês | MEDLINE | ID: mdl-38032851

18.

Transient CD4+ T cell depletion during suppressive ART reduces the HIV reservoir in humanized mice.

Ling, Lijun; De, Chandrav; Spagnuolo, Rae Ann; Begum, Nurjahan; Falcinelli, Shane D; Archin, Nancie M; Kovarova, Martina; Silvestri, Guido; Wahl, Angela; Margolis, David M; Garcia, J Victor.

PLoS Pathog ; 19(12): e1011824, 2023 Dec.

Artigo em Inglês | MEDLINE | ID: mdl-38055722

19.

Timing of initiation of anti-retroviral therapy predicts post-treatment control of SIV replication.

Pinkevych, Mykola; Docken, Steffen S; Okoye, Afam A; Fennessey, Christine M; Del Prete, Gregory Q; Pino, Maria; Harper, Justin L; Betts, Michael R; Paiardini, Mirko; Keele, Brandon F; Davenport, Miles P.

PLoS Pathog ; 19(10): e1011660, 2023 Oct.

Artigo em Inglês | MEDLINE | ID: mdl-37801446

20.

CD8+ cells and small viral reservoirs facilitate post-ART control of SIV replication in M3+ Mauritian cynomolgus macaques initiated on ART two weeks post-infection.

Harwood, Olivia E; Matschke, Lea M; Moriarty, Ryan V; Balgeman, Alexis J; Weaver, Abigail J; Ellis-Connell, Amy L; Weiler, Andrea M; Winchester, Lee C; Fletcher, Courtney V; Friedrich, Thomas C; Keele, Brandon F; O'Connor, David H; Lang, Jessica D; Reynolds, Matthew R; O'Connor, Shelby L.

PLoS Pathog ; 19(9): e1011676, 2023 Sep.

Artigo em Inglês | MEDLINE | ID: mdl-37747933

BVS IEC

Instituto Evandro Chagas

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